Personalized medicine for brain tumors.

The Pacific Pediatric Neuro-Oncology Consortium (PNOC) is a network of more than 20 children’s hospitals that conduct clinical trials of new therapies for children with brain tumors with the mission to identify personalized treatment challenges.

PNOC was formed to provide children with brain tumors access to individual and personalized treatment based on the molecular biology and genetics of each tumor.

Participating hospitals include:

  1. Children’s Hospital Los Angeles (CHLA)
  2. The Children’s Hospital of Philadelphia (CHOP)
  3. Children’s National Medical Center (CNMC)
  4. Johns Hopkins Hospital
  5. Children’s Hospital & Research Center Oakland (CHRCO)
  6. Dana-Farber/Boston Children’s Cancer and Blood Disorders Center (DFCI)
  7. Nationwide Children’s Hospital (Nationwide)
  8.  Doernbecher Children’s Hospital Oregon Health & Science University (OHSU)
  9. Jude Children’s Research Hospital (St Jude)
  10. University of California, Los Angeles (UCLA)
  11. University of California, San Diego Rady Children’s Hospital(UCSD/Rady)
  12. University of California, San Francisco (UCSF)
  13. University of Utah(UTAH)
  14. Seattle Children’s Hospital (Seattle)
  15. Louis Children’s Hospital
  16. Texas Children’s Hospital
  17. University of Minnesota/Masonic Cancer Center
  18. UF Health Neuromedicine Hospital
  19. Ann & Robert H. Lurie Children’s Hospital of Chicago
  20. The Children’s Hospital of Philadelphia
  21. SickKids Hospital

PNOC is running clinical trials like nanoliposomal irinotecan and immunotherapy vaccine (H3.3K27M) for Diffuse Intrinsic Pontine Glioma, modified measles virus for recurrent medulloblastoma, Everolimus for recurrent or progressive low-grade gliomas, Vemurafenib for children with recurrent/ refractory BRAFV600E-mutant gliomas.

To find out if your child is eligible to enroll in a PNOC clinical trial you have to contact the closest participating site.


This page is under construction.

If you would like to provide relevant information or recomendations for this page please send it to

Brain Tumors

Cancer Localisation: Brain , Eye
Treatment: Chemotherapy, Radiation, Surgery

Brain Tumors in a nutshell:

Brain tumors are the second most common type of cancers in children, after Leukemia.

The brain is part of the Nervous System which also includes the eye (Retina) and the main nervous system (Sympathetic Nervous System).

There are about a dozen different types of brain cancers, which can roughly be divided by the following general formula:

Cell types (for example)Location (For exampleName (For Example)
Astrocytoma, Ependymoma, Medulloblastoma etc.Cerebram, Brain-stem, Optical-nerveGlioma, Adenoma, Blastoma, Carcinoma, Sarcoma etc.

A cancer’s name can be comprised of the cell-type alone or a combination of two or more of the above mentioned categories. Here are a few common type’s names:

  • Brain-Stem-Glioma
  • Medullo-Blastoma (The most common type among brain tumors)
  • Optic-Glioma
  • Cerebral-Astrocytoma
  • Rhabdoid Tumors* (The Rhabdoid tumors are mainly formed in the cerebellum or brain stem, however in the past were considered as a sub-type of Wilms tumor (kidneys). Recent and newer conception is seeing Rhabdoid as a sub type of MedulloBlastoma)


External links:

To learn more about Barin cancers and for more links please visit sites such as:

The American Childhood Cancer Organization (ACCO) / Brain

To learn more about Rhabdoid please visit:

The American Childhood Cancer Organization (ACCO) / Rhabdoid
The National Cancer Institute (NCI)


Parents who have been there would also tell you;


This page is under construction.

If you would like to provide relevant information or recomendations for this page please send it to info@MyChild’

See also the interviews on our Testimonials page.